Radioisotopic Imaging of Neuroinflammation: FIGURE 1.

Noninvasive molecular imaging of neuroinflammation

Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous system (CNS) is now recognized to have a constant interplay with the innate and the adaptive immune systems, where resident microglia and infiltrating immune cells from the periphery have important roles. Common diseases o...

Imaging of neuroinflammation in dementia: a review.

We are still very limited in management strategies for dementia, and establishing effective disease modifying therapies based on amyloid or tau remains elusive. Neuroinflammation has been increasingly implicated as a pathological mechanism in dementia and demonstration that it is a key event accelerating cognitive or functional decline would inform novel therapeutic approaches, and may aid diag...

In Vivo Imaging of Human Neuroinflammation.

Neuroinflammation is implicated in the pathophysiology of a growing number of human disorders, including multiple sclerosis, chronic pain, traumatic brain injury, and amyotrophic lateral sclerosis. As a result, interest in the development of novel methods to investigate neuroinflammatory processes, for the purpose of diagnosis, development of new therapies, and treatment monitoring, has surged ...

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Figure Captions. Figure 1. an Example of a Domain

An e cient multigrid approach for solving a discretized elliptic equation whose boundary values are determined in part by integral relations is developed, analyzed and tested. The algorithm is implemented on a problem that is solved during integration of the three-dimensional Quasigeostrophic equations, which model large-scale rotating strati ed ows, where the integral constraints represent mas...